Fully Automated Neuropsychological Assessment for Detecting Mild Cognitive Impairment

We present an end-to-end system for automatically scoring spoken responses to a narrative recall test administered to seniors when screening for cognitive impairment. In Wechsler Logical Memory (WLM) test, a patient listens to a brief narrative, then retells the story once immediately and again after a brief delay. We transcribe the retellings automatically using an ASR system, align the transcripts to the source narrative, extract features that replicate the standard clinical scoring method, and then use the features for automatic assessment using a classifier. On a test corpus of 72 subjects, we empirically evaluate different ASR adaptation strategies and analyze the errors with respect to clinical assessment. Despite imperfect recognition, the system presented here yields classification accuracy comparable to that of manually assigned scores. Our results show that automatic assessment of neuropsychological tests such as the WLM is practical for screening large cohorts.